Enhanced Modulation of Keratinocyte Motility by Transforming Growth Factor-α (TGF-α) Relative to Epidermal Growth Factor (EGF)
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چکیده
منابع مشابه
Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α
heterodimers and possibly higher-order oligomers, following activation by a subset of a dozen potential li-gands including EGF, transforming growth factor ␣ The human EGFR is a large (1186 residues), mono-Parkville, Victoria 3050 Australia meric, modular glycoprotein with an extracellular ligand binding domain, a transmembrane region, and an intra-4 CSIRO Health Sciences and Nutrition 343 Royal...
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Using Northern blot analysis, we have demonstrated that mRNA for transforming growth factor a (TGF-a) was expressed in five malignant kidney tissue specimens but was not detected in their autologous nonneoplastic homologues. In addition, the expression of epidermal growth factor (EGF) receptor mRNA in these malignant tissues was 2to 3-fold greater than in nontransformed tissues. In two cases ex...
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This review describes the discovery and initial characterization of the epidermal growth factors (EGFs) and transforming growth factors alpha (TGF alpha), the biosynthesis and tissue distribution of these molecules and a brief description of the effects of these molecules in culture and animals. An analysis of the similarities between the EGFs and TGF alpha s from different organisms is used to...
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Orderly development requires extensive coordination and communication between cells. Much of this is provided by extracellular proteins (growth factors) that positively and negatively regulate proliferation, differentiation, migration/pathfinding and survival/death. This is achieved via transmembrane receptors that transduce growth factor binding to a cascade of intracellular signaling events t...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1996
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12345083